Abstract Search

ea0099rc11.4 | Rapid Communications 11: Adrenal and Cardiovascular Endocrinology | Part II | ECE2024

Urine steroid metabolomics to diagnose endocrine hypertension: results from the ENS@T-HT project

Prete Alessandro , Abdi Lida , Suntornlohanakul Onnicha , Lang Katharina , Veen Roland , Canducci Marco , Riancho Julien , Lazkani Aida , Larsen Casper K. , Gimenez-Roqueplo Anne-Paule , Pecori Alessio , Tetti Martina , Monticone Silvia , Muller Lisa M. , Adolf Christian , Timmers Henri JLM , Hampson Stephanie , Eisenhofer Graeme , Ceccato Filippo , Beuschlein Felix , Kabat Marek , Bertherat Jerome , Dennedy M. Conall , Davies Eleanor , Deinum Jaap , Reincke Martin , Rossi Gian Paolo , Mulatero Paolo , Amar Laurence , Zennaro Maria-Christina , Sitch Alice J. , Tino Peter , Biehl Michael , Taylor Angela E. , Arlt Wiebke

Background: Hypertension affects more than 30% of the adult population worldwide and is a major cardiovascular risk factor. Identifying secondary causes of hypertension is key to offering targeted treatments and mitigating adverse health outcomes. We tested the performance of urine steroid metabolomics (USM), the computational analysis of 24-hour urine steroid metabolome data by machine learning, for diagnosing endocrine forms of hypertension.Methods: 14...

0 shares

ea0086oc4.4 | Adrenal and Cardiovascular | SFEBES2022

Steroid and global metabolome in benign adrenal tumours with mild autonomous cortisol secretion: analysis by mass spectrometry and machine learning to understand metabolic risk

Prete Alessandro , Abdi Lida , Canducci Marco , Taylor Angela E. , Bancos Irina , Gilligan Lorna C. , Jenkinson Carl , Albors-Zumel Ariadna , van den Brandhof Elina , Zhang Yuanqing , Chortis Vasileios , Tsagarakis Stylianos , Lang Katharina , Macech Magdalena , Delivanis Danae A. , Pupovac Ivana D. , Reimondo Giuseppe , Marina Ljiljana V. , Deutschbein Timo , Balomenaki Maria , O'Reilly Michael W. , Bednarczuk Tomasz , Zhang Catherine D. , Dusek Tina , Diamantopoulos Aristidis , Asia Miriam , Kondracka Agnieszka , Li Dingfeng , Masjkur Jimmy R. , Quinkler Marcus , Ueland Grethe AE. , Conall Dennedy M. , Beuschlein Felix , Tabarin Antoine , Fassnacht Martin , Ivovic Miomira , Terzolo Massimo , Kastelan Darko , Young Jr William F. , Manolopoulos Konstantinos M. , Ambroziak Urszula , Vassiliadi Dimitra A. , Sitch Alice J. , Tino Peter , Biehl Michael , Dunn Warwick B. , Arlt Wiebke

Background: Benign adrenal tumours are found in 3-10% of adults and can be non-functioning (NFAT) or associated with adrenal hormone excess. Analysing 1305 prospectively recruited patients with benign adrenal tumours, we recently demonstrated that 45% had mild autonomous cortisol secretion (MACS), i.e. biochemical cortisol excess without signs of Cushings syndrome (CS). MACS increases the prevalence and severity of hypertension and type 2 diabetes (Ann Int Med. 2022 Doi:...

1 shares

Endocrine Abstracts

Urine steroid metabolomics to diagnose endocrine hypertension: results from the ENS@T-HT project

Steroid and global metabolome in benign adrenal tumours with mild autonomous cortisol secretion: analysis by mass spectrometry and machine learning to understand metabolic risk

BiosciAbstracts